STUDIES ON UREA FORMATION IN SURVIVING LIVER SLICES
نویسندگان
چکیده
منابع مشابه
The effect of various compounds on urea formation by rat liver slices.
In studies on the synthesis of urea in vitro, the nitrogen is usually supplied as NH&l or as (NHJ)$SO~ (l-3). It has been suggested that the mechanism by which such nitrogen enters the cycle and forms urea is somewhat different from that utilized by nitrogen supplied in the form of glutamine or amino acids. Leuthardt and Glasson (2) believe that ammonia from inorganic salts enters the cycle dir...
متن کاملThe Relation of Oxygen Supply to Water Movement and to Urea Formation in Surviving Liver Tissue
Liver slices have been immersed during periods up to 4 hours at 38 degrees C. in Krebs-Ringer solution with bicarbonate buffer and exposed to varied oxygen supply in the presence of carbon dioxide equal to that of venous blood. Water movement, urea, and amino acid formation by the liver tissue have been measured. Water contents of surviving liver tissue diminishes with increased oxygen supply, ...
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The biosynthesis of urea in vifro was maintained at a constant rate for 48 hours in a surviving amphibian liver cube system. The maintenance of constant oxygen consumption and protein synthesis during this time indicated that the majority of cells remained viable. A direct correlation between the rate of lixation of 14C02 and ammonia into urea and the levels of carbamyl phosphate synthetase in ...
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Evidence has been produced in this and other laboratories that the impaired capacity to excrete sodium which characterizes a number of clinical states involving edema, ascites and anasarca, is mediated, in part at least, through a humoral factor emanating, in all probability, from the adrenal cortex (1-8). It now appears almost certain, on the basis of available evidence, that this substance, g...
متن کامل86. Urea Formation in Mammalian Liver
Leuthardt [1938a] and Bach [1939] have expressed the opinion that in addition to the ornithine cycle there are other mechanisms of urea synthesis in the mammalian liver. Leuthardt [1938a] found that liver of starved guinea-pigs forms urea more rapidly from glutamine than from NH4Cl. He concluded that NH3 cannot be an intermediate in the urea formation from glutamine and that there is a more or ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1950
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)56237-2